Browse Pet Safety Reports
15,703 FDA adverse event reports for pets.
FDA Veterinary Adverse Event Database
Browse 15,703 adverse event reports collected by the FDA's Center for Veterinary Medicine. Each report includes the animal species, breed, drug or product involved, observed reactions, and outcome. Reports flagged as "serious" involve death, life-threatening conditions, or hospitalization. Use the filters to narrow results by species, outcome severity, or keyword. Note that a higher number of reports does not necessarily indicate a less safe product, widely prescribed drugs naturally accumulate more reports.
Pet Adverse Event Reports
Browse 15,703 FDA veterinary adverse event reports.
| Date | Species | Breed | Drug | Reaction | Outcome |
|---|---|---|---|---|---|
| Jan 8, 2016 | Cat | Domestic Shorthair | Praziquantel; Emodepside | Hypersalivation; Lethargy (see also Central nervous system depression in 'Neu... | Outcome Unknown |
| Jan 8, 2016 | Cat | Domestic Mediumhair | Imidacloprid; Moxidectin | Hyperactivity; Hypersalivation; Twitching | Outcome Unknown |
| Jan 7, 2016 | Dog | Dog (unknown) | Afoxolaner 28.3 Mg Chewable Tablets | Emesis; Hypersalivation; Anorexia; Dysuria; Distension of abdomen | Outcome Unknown |
| Jan 5, 2016 | Cat | Domestic Shorthair | Praziquantel; Emodepside | Hypersalivation; Anorexia; Lethargy (see also Central nervous system depressi... | Recovered/Normal |
| Jan 5, 2016 | Dog | Shih Tzu | Afoxolaner | Seizure NOS; Hypersalivation; Pale mucous membrane; Panting; Paddling | Outcome Unknown |
| Jan 4, 2016 | Dog | Retriever - Labrador | Spinosad; Milbemycin Oxime | Lethargy (see also Central nervous system depression in 'Neurological'); Naus... | Recovered/Normal |
| Jan 3, 2016 | Dog | Bulldog - French | Spinosad | Vomiting; Nausea; Hypersalivation | Outcome Unknown |
| Jan 1, 2016 | Dog | Maltese | Spinosad; Milbemycin Oxime | Vomiting; Hypersalivation | Ongoing |
| Jan 1, 2016 | Cat | Cat (unknown) | Cyclosporine | Hypersalivation | Outcome Unknown |
| Jan 1, 2016 | Cat | Domestic Shorthair | Cyclosporine | Hypersalivation; Foaming at the mouth | Recovered/Normal |
| Jan 1, 2016 | Dog | Poodle - Miniature | Milbemycin Oxime; Praziquantel | Seizure NOS; Pyoderma; Hypersalivation | Ongoing |
| Jan 1, 2016 | Cat | Cat (unknown) | Cyclosporine | Hypersalivation | Outcome Unknown |
| Dec 31, 2015 | Cat | Domestic Shorthair | Praziquantel; Emodepside | Hypersalivation; Hiding; Accidental exposure | Outcome Unknown |
| Dec 31, 2015 | Dog | Terrier - Jack Russell | Cefovecin | Hypersalivation; Foaming at the mouth; Tic(s); Ataxia; Tremor; Seizure NOS; R... | Ongoing |
| Dec 30, 2015 | Cat | Domestic Shorthair | Praziquantel; Emodepside | Hypersalivation; Ataxia; Lethargy (see also Central nervous system depression... | Outcome Unknown |
| Dec 30, 2015 | Cat | Domestic Shorthair | Imidacloprid; Moxidectin | Hypersalivation; Overdose | Outcome Unknown |
| Dec 30, 2015 | Cat | Maine Coon | Cyclosporine | Hypersalivation; Vomiting | Ongoing |
| Dec 24, 2015 | Dog | Bulldog - French | Milbemycin Oxime, Lufenuron | Vomiting; Restlessness; Mucous stool; Lethargy (see also Central nervous syst... | Outcome Unknown |
| Dec 22, 2015 | Dog | Mixed (Dog) | Afoxolaner | Seizure NOS; Hypersalivation; Ataxia; Pacing; Panting | Outcome Unknown |
| Dec 21, 2015 | Dog | Unknown | Ketamine Hcl | Hyperactivity; Vomiting; Hypersalivation; Rough recovery | Recovered/Normal |
| Dec 21, 2015 | Cat | Domestic Longhair | Pradofloxacin | Hypersalivation | Outcome Unknown |
| Dec 21, 2015 | Cat | Domestic Longhair | Pradofloxacin | Hypersalivation | Outcome Unknown |
| Dec 20, 2015 | Dog | Pit Bull | Imidacloprid; Moxidectin | Panting; Hypersalivation; Ataxia; Incorrect route of drug administration | Outcome Unknown |
| Dec 20, 2015 | Dog | Pit Bull | Afoxolaner | Paddling; Hypersalivation; Urinary incontinence; Involuntary defecation; Seiz... | Outcome Unknown |
| Dec 19, 2015 | Dog | Crossbred Canine/dog | Spinosad; Milbemycin Oxime | Lethargy (see also Central nervous system depression in 'Neurological'); Hype... | Outcome Unknown |
| Dec 18, 2015 | Dog | Crossbred Canine/dog, Sheph... | Fluralaner Chew Tablets | Hypersalivation; Lip disorder NOS | Recovered/Normal |
| Dec 18, 2015 | Dog | Shepherd Dog - German | Afoxolaner | Hypersalivation; Stumbling gait | Outcome Unknown |
| Dec 17, 2015 | Cat | Domestic Shorthair | Buprenorphine | Hypersalivation; Hypersensitivity NOS; Hyperactivity; Dilated pupils | Recovered/Normal |
| Dec 15, 2015 | Dog | Hound - Basset | Fluralaner Chew Tablets | Hypersalivation; Tremor of limb; Not drinking; Depression; Head pressing; Tre... | Recovered/Normal |
| Dec 15, 2015 | Dog | Bulldog | Melarsomine Dihydrochloride Injection | Pain NOS; Hypersalivation; Panting; Tachycardia; Fever | Recovered/Normal |
| Dec 14, 2015 | Cat | Domestic Shorthair | Praziquantel; Emodepside | Hypersalivation | Outcome Unknown |
| Dec 14, 2015 | Dog | Boxer (German Boxer) | Ivermectin 272Mcg, Pyrantel Pamoate 2... | Anorexia; Hypersalivation; Aggression; Weight loss; Death by euthanasia | Euthanized |
| Dec 13, 2015 | Horse | Horse (unknown) | Ivermectin(1.55%)/Praziquantel(7.75%)... | Swollen mouth; Mouth pain; Hypersalivation; Anorexia | Recovered/Normal |
| Dec 11, 2015 | Cat | Domestic Shorthair | Cefovecin | Head bobbing; Hypersalivation; Tachycardia | Ongoing |
| Dec 10, 2015 | Dog | Bulldog - American | Maropitant Citrate | Hypersalivation | Recovered/Normal |
| Dec 9, 2015 | Cat | Domestic Shorthair | Imidacloprid; Moxidectin | Hypersalivation; Incorrect dose administered NOS; Underdose | Outcome Unknown |
| Dec 9, 2015 | Cat | Cat (other) | Selamectin | Hypersalivation; Dilated pupils | Recovered/Normal |
| Dec 7, 2015 | Dog | Akita | Imidacloprid; Moxidectin | Vomiting; Hypersalivation; Lethargy (see also Central nervous system depressi... | Outcome Unknown |
| Dec 6, 2015 | Dog | Spaniel - Cocker American | Imidacloprid; Moxidectin | Lethargy (see also Central nervous system depression in 'Neurological'); Atax... | Outcome Unknown |
| Dec 3, 2015 | Dog | Retriever - Labrador | Deracoxib | Neutrophilia; Lymphopenia; Emesis (multiple); Joint pain; Behavioural disorde... | Euthanized |
| Dec 3, 2015 | Cat | Domestic Shorthair | Imidacloprid; Moxidectin | Hypersalivation; Limb weakness; Ataxia; Lethargy (see also Central nervous sy... | Outcome Unknown |
| Dec 2, 2015 | Dog | Chihuahua | Praziquantel | Hypersalivation; Anorexia; Emesis (multiple) | Recovered/Normal |
| Dec 2, 2015 | Cat | Domestic Shorthair | Imidacloprid; Moxidectin | Hypersalivation | Recovered/Normal |
| Dec 2, 2015 | Cat | Domestic Shorthair | Imidacloprid; Moxidectin | Hypersalivation | Recovered/Normal |
| Dec 1, 2015 | Dog | Boxer (German Boxer) | Melarsomine Dihydrochloride Injection | Panting; Hypersalivation | Outcome Unknown |
| Dec 1, 2015 | Dog | Pug | Afoxolaner 68 Mg Chewable Tablets | Hypersalivation; Lethargy (see also Central nervous system depression in 'Neu... | Recovered/Normal |
| Dec 1, 2015 | Cat | Domestic Mediumhair | Praziquantel; Emodepside | Seizure NOS; Tongue protrusion; Hypersalivation; Tachypnoea; Tongue disorder ... | Euthanized |
| Dec 1, 2015 | Dog | Dog (unknown) | Oclacitinib Maleate | Hypersalivation; Emesis | Recovered/Normal |
| Dec 1, 2015 | Cat | Domestic Shorthair | Cyclosporine | Hypersalivation; Lack of efficacy - NOS; Diabetes; Weight loss | Ongoing |
| Nov 29, 2015 | Cat | Domestic Shorthair | Imidacloprid; Moxidectin | Hyperactivity; Hypersalivation; Vocalisation; Faecal incontinence; Urinary in... | Euthanized |
Frequently Asked Questions
Contact your veterinarian immediately. If the reaction is severe, difficulty breathing, seizures, collapse, or severe swelling, seek emergency veterinary care right away. After your pet is stabilized, report the adverse event to the FDA through safetyreporting.hhs.gov or by calling 1-888-FDA-VETS (1-888-332-8387). Reporting helps the FDA identify safety issues that can lead to label changes or product recalls.
Dogs account for the majority of adverse event reports, followed by cats. This reflects both the larger pet population and wider range of medications for these species. Flea and tick products, pain medications (NSAIDs), and heartworm preventives are among the product categories with the highest report counts across all species.
Not necessarily. A drug used by millions of pets will have more reports in absolute numbers than a niche product, even if the actual rate of adverse events is lower. The FDA uses these reports as one of many tools to evaluate drug safety, looking for patterns and statistical signals rather than raw counts alone. Always consult your veterinarian before changing any medication.