Browse Pet Safety Reports

15,703 FDA adverse event reports for pets.

FDA Veterinary Adverse Event Database

Browse 15,703 adverse event reports collected by the FDA's Center for Veterinary Medicine. Each report includes the animal species, breed, drug or product involved, observed reactions, and outcome. Reports flagged as "serious" involve death, life-threatening conditions, or hospitalization. Use the filters to narrow results by species, outcome severity, or keyword. Note that a higher number of reports does not necessarily indicate a less safe product, widely prescribed drugs naturally accumulate more reports.

Pet Adverse Event Reports

Browse 15,703 FDA veterinary adverse event reports.

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Date Species Breed Drug Reaction Outcome
Jan 8, 2016 Cat Domestic Shorthair Praziquantel; Emodepside Hypersalivation; Lethargy (see also Central nervous system depression in 'Neu... Outcome Unknown
Jan 8, 2016 Cat Domestic Mediumhair Imidacloprid; Moxidectin Hyperactivity; Hypersalivation; Twitching Outcome Unknown
Jan 7, 2016 Dog Dog (unknown) Afoxolaner 28.3 Mg Chewable Tablets Emesis; Hypersalivation; Anorexia; Dysuria; Distension of abdomen Outcome Unknown
Jan 5, 2016 Cat Domestic Shorthair Praziquantel; Emodepside Hypersalivation; Anorexia; Lethargy (see also Central nervous system depressi... Recovered/Normal
Jan 5, 2016 Dog Shih Tzu Afoxolaner Seizure NOS; Hypersalivation; Pale mucous membrane; Panting; Paddling Outcome Unknown
Jan 4, 2016 Dog Retriever - Labrador Spinosad; Milbemycin Oxime Lethargy (see also Central nervous system depression in 'Neurological'); Naus... Recovered/Normal
Jan 3, 2016 Dog Bulldog - French Spinosad Vomiting; Nausea; Hypersalivation Outcome Unknown
Jan 1, 2016 Dog Maltese Spinosad; Milbemycin Oxime Vomiting; Hypersalivation Ongoing
Jan 1, 2016 Cat Cat (unknown) Cyclosporine Hypersalivation Outcome Unknown
Jan 1, 2016 Cat Domestic Shorthair Cyclosporine Hypersalivation; Foaming at the mouth Recovered/Normal
Jan 1, 2016 Dog Poodle - Miniature Milbemycin Oxime; Praziquantel Seizure NOS; Pyoderma; Hypersalivation Ongoing
Jan 1, 2016 Cat Cat (unknown) Cyclosporine Hypersalivation Outcome Unknown
Dec 31, 2015 Cat Domestic Shorthair Praziquantel; Emodepside Hypersalivation; Hiding; Accidental exposure Outcome Unknown
Dec 31, 2015 Dog Terrier - Jack Russell Cefovecin Hypersalivation; Foaming at the mouth; Tic(s); Ataxia; Tremor; Seizure NOS; R... Ongoing
Dec 30, 2015 Cat Domestic Shorthair Praziquantel; Emodepside Hypersalivation; Ataxia; Lethargy (see also Central nervous system depression... Outcome Unknown
Dec 30, 2015 Cat Domestic Shorthair Imidacloprid; Moxidectin Hypersalivation; Overdose Outcome Unknown
Dec 30, 2015 Cat Maine Coon Cyclosporine Hypersalivation; Vomiting Ongoing
Dec 24, 2015 Dog Bulldog - French Milbemycin Oxime, Lufenuron Vomiting; Restlessness; Mucous stool; Lethargy (see also Central nervous syst... Outcome Unknown
Dec 22, 2015 Dog Mixed (Dog) Afoxolaner Seizure NOS; Hypersalivation; Ataxia; Pacing; Panting Outcome Unknown
Dec 21, 2015 Dog Unknown Ketamine Hcl Hyperactivity; Vomiting; Hypersalivation; Rough recovery Recovered/Normal
Dec 21, 2015 Cat Domestic Longhair Pradofloxacin Hypersalivation Outcome Unknown
Dec 21, 2015 Cat Domestic Longhair Pradofloxacin Hypersalivation Outcome Unknown
Dec 20, 2015 Dog Pit Bull Imidacloprid; Moxidectin Panting; Hypersalivation; Ataxia; Incorrect route of drug administration Outcome Unknown
Dec 20, 2015 Dog Pit Bull Afoxolaner Paddling; Hypersalivation; Urinary incontinence; Involuntary defecation; Seiz... Outcome Unknown
Dec 19, 2015 Dog Crossbred Canine/dog Spinosad; Milbemycin Oxime Lethargy (see also Central nervous system depression in 'Neurological'); Hype... Outcome Unknown
Dec 18, 2015 Dog Crossbred Canine/dog, Sheph... Fluralaner Chew Tablets Hypersalivation; Lip disorder NOS Recovered/Normal
Dec 18, 2015 Dog Shepherd Dog - German Afoxolaner Hypersalivation; Stumbling gait Outcome Unknown
Dec 17, 2015 Cat Domestic Shorthair Buprenorphine Hypersalivation; Hypersensitivity NOS; Hyperactivity; Dilated pupils Recovered/Normal
Dec 15, 2015 Dog Hound - Basset Fluralaner Chew Tablets Hypersalivation; Tremor of limb; Not drinking; Depression; Head pressing; Tre... Recovered/Normal
Dec 15, 2015 Dog Bulldog Melarsomine Dihydrochloride Injection Pain NOS; Hypersalivation; Panting; Tachycardia; Fever Recovered/Normal
Dec 14, 2015 Cat Domestic Shorthair Praziquantel; Emodepside Hypersalivation Outcome Unknown
Dec 14, 2015 Dog Boxer (German Boxer) Ivermectin 272Mcg, Pyrantel Pamoate 2... Anorexia; Hypersalivation; Aggression; Weight loss; Death by euthanasia Euthanized
Dec 13, 2015 Horse Horse (unknown) Ivermectin(1.55%)/Praziquantel(7.75%)... Swollen mouth; Mouth pain; Hypersalivation; Anorexia Recovered/Normal
Dec 11, 2015 Cat Domestic Shorthair Cefovecin Head bobbing; Hypersalivation; Tachycardia Ongoing
Dec 10, 2015 Dog Bulldog - American Maropitant Citrate Hypersalivation Recovered/Normal
Dec 9, 2015 Cat Domestic Shorthair Imidacloprid; Moxidectin Hypersalivation; Incorrect dose administered NOS; Underdose Outcome Unknown
Dec 9, 2015 Cat Cat (other) Selamectin Hypersalivation; Dilated pupils Recovered/Normal
Dec 7, 2015 Dog Akita Imidacloprid; Moxidectin Vomiting; Hypersalivation; Lethargy (see also Central nervous system depressi... Outcome Unknown
Dec 6, 2015 Dog Spaniel - Cocker American Imidacloprid; Moxidectin Lethargy (see also Central nervous system depression in 'Neurological'); Atax... Outcome Unknown
Dec 3, 2015 Dog Retriever - Labrador Deracoxib Neutrophilia; Lymphopenia; Emesis (multiple); Joint pain; Behavioural disorde... Euthanized
Dec 3, 2015 Cat Domestic Shorthair Imidacloprid; Moxidectin Hypersalivation; Limb weakness; Ataxia; Lethargy (see also Central nervous sy... Outcome Unknown
Dec 2, 2015 Dog Chihuahua Praziquantel Hypersalivation; Anorexia; Emesis (multiple) Recovered/Normal
Dec 2, 2015 Cat Domestic Shorthair Imidacloprid; Moxidectin Hypersalivation Recovered/Normal
Dec 2, 2015 Cat Domestic Shorthair Imidacloprid; Moxidectin Hypersalivation Recovered/Normal
Dec 1, 2015 Dog Boxer (German Boxer) Melarsomine Dihydrochloride Injection Panting; Hypersalivation Outcome Unknown
Dec 1, 2015 Dog Pug Afoxolaner 68 Mg Chewable Tablets Hypersalivation; Lethargy (see also Central nervous system depression in 'Neu... Recovered/Normal
Dec 1, 2015 Cat Domestic Mediumhair Praziquantel; Emodepside Seizure NOS; Tongue protrusion; Hypersalivation; Tachypnoea; Tongue disorder ... Euthanized
Dec 1, 2015 Dog Dog (unknown) Oclacitinib Maleate Hypersalivation; Emesis Recovered/Normal
Dec 1, 2015 Cat Domestic Shorthair Cyclosporine Hypersalivation; Lack of efficacy - NOS; Diabetes; Weight loss Ongoing
Nov 29, 2015 Cat Domestic Shorthair Imidacloprid; Moxidectin Hyperactivity; Hypersalivation; Vocalisation; Faecal incontinence; Urinary in... Euthanized

Frequently Asked Questions

Contact your veterinarian immediately. If the reaction is severe, difficulty breathing, seizures, collapse, or severe swelling, seek emergency veterinary care right away. After your pet is stabilized, report the adverse event to the FDA through safetyreporting.hhs.gov or by calling 1-888-FDA-VETS (1-888-332-8387). Reporting helps the FDA identify safety issues that can lead to label changes or product recalls.

Dogs account for the majority of adverse event reports, followed by cats. This reflects both the larger pet population and wider range of medications for these species. Flea and tick products, pain medications (NSAIDs), and heartworm preventives are among the product categories with the highest report counts across all species.

Not necessarily. A drug used by millions of pets will have more reports in absolute numbers than a niche product, even if the actual rate of adverse events is lower. The FDA uses these reports as one of many tools to evaluate drug safety, looking for patterns and statistical signals rather than raw counts alone. Always consult your veterinarian before changing any medication.