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Consumer Safety

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Pet Safety Statistics

Data and trends from 1,332,683 FDA veterinary adverse event reports. Drug reactions, outcomes, and species breakdown.

0 Total Reports
0 Serious Events
0 Fatalities
0 Recovered

Adverse Event Reports by Year

Number of FDA veterinary adverse event reports filed per year.

Most Reported Drugs

Active ingredients with the highest number of adverse event reports.

#Active IngredientReports
1 Spinosad; Milbemycin Oxime 133,859
2 Ivermectin; Pyrantel As Pamoate Salt 81,401
3 Spinosad 70,979
4 Selamectin 59,979
5 Moxidectin 52,852
6 Pyrantel Pamoate;Sarolaner 47,964
7 Afoxolaner 46,339
8 Carprofen 43,497
9 Ivermectin, Pyrantel 39,299
10 Fluralaner Chew Tablets 35,404
11 Milbemycin Oxime; Praziquantel 27,612
12 Fluralaner 13.64% 12-Week Chew 25,487
13 Oclacitinib Maleate 23,886
14 Milbemycin 23,037
15 Nitenpyram 18,895

Most Common Reactions

Most frequently reported adverse reactions in animals.

#ReactionReports
1 Vomiting 211,736
2 Depression 133,069
3 Lethargy 91,661
4 Death 82,154
5 Anorexia 59,694
6 Seizure 34,351
7 Ataxia 33,293
8 Pruritus 29,491
9 Weight Loss 23,590
10 Alopecia 18,026
11 Salivation 16,317
12 Hypersalivation 15,703
13 Weakness 15,484
14 Polydipsia 13,963
15 Trembling/Tremor 13,011

Most Reported Breeds

Animal breeds with the highest number of adverse event reports.

#BreedReports
1 Retriever - Labrador 97,599
2 Crossbred Canine/dog 95,275
3 Domestic Shorthair 62,307
4 Dog (unknown) 55,513
5 Shepherd Dog - German 34,560
6 Retriever - Golden 33,119
7 Chihuahua 28,018
8 Domestic (unspecified) 27,284
9 Terrier - Yorkshire 24,679
10 Shih Tzu 23,793
11 Boxer (German Boxer) 20,158
12 Beagle 18,112
13 Pit Bull 16,676
14 Cat (unknown) 16,233
15 Dachshund (unspecified) 15,724
16 Shepherd Dog - Australian 14,941
17 Terrier - Jack Russell 11,120
18 Maltese 10,739
19 Pug 9,394
20 Spitz - German Pomeranian 9,360

Reports by Species

Adverse event reports filed per animal species.

SpeciesReports
Dog 969,382
Cat 143,870
Cattle 31,013
Horse 18,045
Human 16,698
Pig 2,598
Other 1,493
Sheep 1,068
Chicken 1,059
Goat 823
Turkey 517
Rabbit 505
Ferret 369
Other Birds 210
Fish 208

About This Data

All pet adverse event data comes from the FDA's Center for Veterinary Medicine through the openFDA public data program. The FDA publishes quarterly data files containing reports from veterinarians, pet owners, and drug manufacturers. Our database contains 1,332,683 reports.

Not necessarily. Popular drugs prescribed to millions of animals will naturally accumulate more reports than niche products, even if the rate of adverse events is lower. Reporting is voluntary in many cases. These reports are a signal for further investigation, not a verdict on drug safety. Always consult your veterinarian.

An adverse event is classified as "serious" when it results in death, a life-threatening condition, hospitalization, disability, or a congenital anomaly. In our database, 333,219 reports (25%) are classified as serious. Of these, 66,122 resulted in death and 19,437 in euthanasia.