Browse Pet Safety Reports

1,493 FDA adverse event reports for pets.

FDA Veterinary Adverse Event Database

Browse 1,493 adverse event reports collected by the FDA's Center for Veterinary Medicine. Each report includes the animal species, breed, drug or product involved, observed reactions, and outcome. Reports flagged as "serious" involve death, life-threatening conditions, or hospitalization. Use the filters to narrow results by species, outcome severity, or keyword. Note that a higher number of reports does not necessarily indicate a less safe product — widely prescribed drugs naturally accumulate more reports.

Pet Adverse Event Reports

Browse 1,493 FDA veterinary adverse event reports for Other.

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Date Species Breed Drug Reaction Outcome
Apr 15, 1994 Other Unknown Isoflurane Death Died
Mar 17, 1994 Other Unknown Pentobarbital, Phenytoin Lack of efficacy - NOS Died
Mar 1, 1994 Other Unknown Tiletamine, Zolazepam INEFFECTIVE, ANESTHESIA
Feb 23, 1994 Other Unknown Ketamine Hydrochloride Uraemia; Convulsion; Fever; Peripheral nervous system disorder NOS
Feb 21, 1994 Other Unknown Tiletamine, Zolazepam INEFFECTIVE, ANESTHESIA
Feb 9, 1994 Other Unknown Ketamine Hydrochloride Cardiac arrest; Convulsion
Feb 8, 1994 Other Unknown Tiletamine, Zolazepam INEFFECTIVE, ANESTHESIA
Feb 8, 1994 Other Unknown Ketamine Hydrochloride INEFFECTIVE, ANESTHESIA
Feb 7, 1994 Other Unknown Tiletamine, Zolazepam Cardiac arrest; Apnoea; Death Died
Dec 28, 1993 Other Unknown Amoxicillin Injection site pain
Dec 17, 1993 Other Unknown Cefadroxil Unclassifiable adverse event
Dec 17, 1993 Other Unknown Cefadroxil Defect Unknown/Not Specified
Dec 10, 1993 Other Unknown Ketamine Hydrochloride INEFFECTIVE, ANESTHESIA
Nov 19, 1993 Other Unknown Pentobarbital, Phenytoin INEFFECTIVE, EUTHANASIA Died
Nov 19, 1993 Other Unknown Pentobarbital, Phenytoin INEFFECTIVE, EUTHANASIA Died
Sep 16, 1993 Other Unknown Chorionic Gonadotropin INEFFECTIVE, OVULATION
Aug 31, 1993 Other Unknown Ketamine Hydrochloride INEFFECTIVE, ANESTHESIA
Jun 14, 1993 Other Unknown Tiletamine, Zolazepam Pulmonary congestion; PR-LUNG(S), LESION(S); Apnoea; Death Died
Jun 10, 1993 Other Unknown Bacitracin, Neomycin, Polymyxin B Corneal ulcer
Jun 7, 1993 Other Unknown Ketamine Hydrochloride INEFFECTIVE, ANESTHESIA
May 26, 1993 Other Unknown Pentobarbital, Phenytoin Lack of efficacy - NOS Died
May 26, 1993 Other Unknown Pentobarbital, Phenytoin Lack of efficacy - NOS Died
May 4, 1993 Other Unknown Ketamine Hydrochloride INEFFECTIVE, ANESTHESIA
Feb 22, 1993 Other Unknown Tiletamine, Zolazepam INEFFECTIVE, ANESTHESIA; Death Died
Jan 27, 1993 Other Unknown Epsiprantel Lack of efficacy (endoparasite) - tapeworm
Aug 31, 1992 Other Unknown Ketamine Hydrochloride INEFFECTIVE, ANESTHESIA
Jun 12, 1992 Other Unknown Pentobarbital, Phenytoin Lack of efficacy - NOS
Apr 16, 1992 Other Unknown Tiletamine, Zolazepam INEFFECTIVE, ANESTHESIA
Mar 23, 1992 Other Unknown Acepromazine Maleate Apnoea; Death Died
Feb 10, 1992 Other Unknown Tiletamine, Zolazepam Lack of efficacy - NOS
Apr 23, 1991 Other Unknown Ketamine Hydrochloride Death Died
Mar 12, 1991 Other Unknown N-Butyl Chloride Lack of efficacy - NOS
Oct 23, 1990 Other Unknown Monensin Death Died
Jul 17, 1990 Other Unknown Thiamylal INEFFECTIVE, ANESTHESIA
Jul 17, 1990 Other Unknown Thiamylal Unclassifiable adverse event
Jul 10, 1990 Other Unknown Ivermectin Death; Stupor Died
Jun 4, 1990 Other Unknown Xylazine INEFFECTIVE, ANESTHESIA
May 8, 1990 Other Unknown Ivermectin Bloody diarrhoea; Enteritis; Death Died
May 4, 1990 Other Unknown Ivermectin Death Died
Dec 1, 1989 Other Unknown Methylprednisolone Acetate Lack of efficacy - NOS
Dec 1, 1989 Other Unknown Methylprednisolone Acetate Lack of efficacy - NOS
Oct 31, 1989 Other Unknown Fenbendazole Death; Weight loss; PR-KIDNEY(S), LESION(S); PR-INTEST, LESION(S); Vomiting; ... Died
Oct 20, 1989 Other Unknown Fenbendazole Lack of efficacy - NOS
Oct 6, 1989 Other Unknown Amoxicillin Injection site pain
Oct 6, 1989 Other Unknown Amoxicillin Injection site pain
Aug 1, 1989 Other Unknown Xylazine Lack of efficacy - NOS
Jun 2, 1989 Other Unknown Pentobarbital, Phenytoin Lack of efficacy - NOS Died
Apr 6, 1989 Other Unknown Tiletamine, Zolazepam Death Died
Feb 24, 1989 Other Unknown Xylazine INEFFECTIVE, SEDATION
Dec 7, 1988 Other Unknown Ketamine Hydrochloride INEFFECTIVE, ANESTHESIA

Frequently Asked Questions

Contact your veterinarian immediately. If the reaction is severe — difficulty breathing, seizures, collapse, or severe swelling — seek emergency veterinary care right away. After your pet is stabilized, report the adverse event to the FDA through safetyreporting.hhs.gov or by calling 1-888-FDA-VETS (1-888-332-8387). Reporting helps the FDA identify safety issues that can lead to label changes or product recalls.

Dogs account for the majority of adverse event reports, followed by cats. This reflects both the larger pet population and wider range of medications for these species. Flea and tick products, pain medications (NSAIDs), and heartworm preventives are among the product categories with the highest report counts across all species.

Not necessarily. A drug used by millions of pets will have more reports in absolute numbers than a niche product, even if the actual rate of adverse events is lower. The FDA uses these reports as one of many tools to evaluate drug safety, looking for patterns and statistical signals rather than raw counts alone. Always consult your veterinarian before changing any medication.