Browse Pet Safety Reports

1,493 FDA adverse event reports for pets.

FDA Veterinary Adverse Event Database

Browse 1,493 adverse event reports collected by the FDA's Center for Veterinary Medicine. Each report includes the animal species, breed, drug or product involved, observed reactions, and outcome. Reports flagged as "serious" involve death, life-threatening conditions, or hospitalization. Use the filters to narrow results by species, outcome severity, or keyword. Note that a higher number of reports does not necessarily indicate a less safe product — widely prescribed drugs naturally accumulate more reports.

Pet Adverse Event Reports

Browse 1,493 FDA veterinary adverse event reports for Other.

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Date Species Breed Drug Reaction Outcome
Jan 22, 1996 Other Unknown Pentobarbital, Phenytoin Lack of efficacy - NOS Died
Jan 22, 1996 Other Unknown Pentobarbital, Phenytoin Lack of efficacy - NOS Died
Jan 22, 1996 Other Unknown Pentobarbital, Phenytoin Lack of efficacy - NOS Died
Jan 22, 1996 Other Unknown Pentobarbital, Phenytoin Lack of efficacy - NOS Died
Jan 22, 1996 Other Unknown Pentobarbital, Phenytoin Lack of efficacy - NOS Died
Jan 22, 1996 Other Unknown Pentobarbital, Phenytoin Lack of efficacy - NOS Died
Jan 22, 1996 Other Unknown Pentobarbital, Phenytoin Lack of efficacy - NOS Died
Dec 14, 1995 Other Unknown Xylazine INEFFECTIVE, SEDATION
Nov 27, 1995 Other Unknown Ketamine Hydrochloride Death Died
Nov 1, 1995 Other Unknown Ampicillin Trihydrate Injection site pain
Oct 3, 1995 Other Unknown Methylprednisolone Acetate Uraemia; Hepatopathy; Hyperglycaemia; Death Died
Aug 21, 1995 Other Unknown Methoxyflurane INEFFECTIVE, ANESTHESIA
Aug 8, 1995 Other Unknown Ketamine Hydrochloride INEFFECTIVE, ANESTHESIA
Jul 31, 1995 Other Unknown Butorphanol Tartrate Bradycardia; Cardiac arrest; Bradypnoea
Jul 20, 1995 Other Unknown Isoflurane INEFFECTIVE, ANESTHESIA
Jul 13, 1995 Other Unknown Ketamine Hydrochloride INEFFECTIVE, ANESTHESIA
Jul 13, 1995 Other Unknown Ketamine Hydrochloride Cardiac arrest; Death Died
Jul 13, 1995 Other Unknown Ketamine Hydrochloride INEFFECTIVE, ANESTHESIA
Jul 13, 1995 Other Unknown Ketamine Hydrochloride Cyanosis
Jul 5, 1995 Other Unknown Praziquantel Injection site pain
Jun 23, 1995 Other Unknown Pentobarbital, Phenytoin Lack of efficacy - NOS
Jun 20, 1995 Other Unknown Ivermectin Paralysis
Jun 14, 1995 Other Unknown Pentobarbital, Phenytoin Lack of efficacy - NOS
May 30, 1995 Other Unknown Pentobarbital, Phenytoin Lack of efficacy - NOS
May 30, 1995 Other Unknown Pentobarbital, Phenytoin Lack of efficacy - NOS
Apr 12, 1995 Other Unknown Pentobarbital, Phenytoin Lack of efficacy - NOS
Mar 13, 1995 Other Unknown Ketamine Hydrochloride INEFFECTIVE, ANESTHESIA
Mar 3, 1995 Other Unknown Ivermectin Apnoea; Death; Collapse (see also 'Cardio-vascular' and 'Systemic disorders') Died
Feb 14, 1995 Other Unknown Ketamine Hydrochloride INEFFECTIVE, ANESTHESIA; Death Died
Feb 9, 1995 Other Unknown Ampicillin Trihydrate Injection site swelling
Feb 8, 1995 Other Unknown Tiletamine, Zolazepam No sign
Feb 8, 1995 Other Unknown Tiletamine, Zolazepam Prolonged anaesthesia
Feb 6, 1995 Other Unknown Bacitracin, Neomycin, Polymyxin B Corneal ulcer
Feb 6, 1995 Other Unknown Bacitracin, Neomycin, Polymyxin B Eye irritation
Jan 23, 1995 Other Unknown Acepromazine Maleate INEFFECTIVE, TRANQUILIZATION
Jan 18, 1995 Other Unknown Ketamine Hydrochloride Swelling NOS; Ulceration NOS; Death; INEFFECTIVE, ANESTHESIA Died
Dec 19, 1994 Other Unknown Ivermectin Cardiac disorder NOS; Death Died
Nov 23, 1994 Other Unknown Pentobarbital, Phenytoin Lack of efficacy - NOS Died
Oct 26, 1994 Other Unknown Famphur Regurgitation Died
Oct 19, 1994 Other Unknown Amprolium Death Died
Sep 9, 1994 Other Unknown Amoxicillin Injection site pain
Aug 26, 1994 Other Unknown Amoxicillin Injection site pain
Aug 10, 1994 Other Unknown Pentobarbital, Phenytoin Lack of efficacy - NOS Died
Jul 29, 1994 Other Unknown Pentobarbital, Phenytoin Lack of efficacy - NOS Died
Jun 23, 1994 Other Unknown Ketamine Hydrochloride INEFFECTIVE, SEDATION
Jun 15, 1994 Other Unknown Pentobarbital, Phenytoin Lack of efficacy - NOS Died
May 16, 1994 Other Unknown Sulfadimethoxine Death Died
May 9, 1994 Other Unknown Ivermectin Ataxia; Recumbency; Death Died
May 4, 1994 Other Unknown Methoxyflurane Lack of efficacy - NOS
Apr 29, 1994 Other Unknown Dexamethasone Sodium Phosphate Cardiac arrest; Apnoea; Collapse (see also 'Cardio-vascular' and 'Systemic di...

Frequently Asked Questions

Contact your veterinarian immediately. If the reaction is severe — difficulty breathing, seizures, collapse, or severe swelling — seek emergency veterinary care right away. After your pet is stabilized, report the adverse event to the FDA through safetyreporting.hhs.gov or by calling 1-888-FDA-VETS (1-888-332-8387). Reporting helps the FDA identify safety issues that can lead to label changes or product recalls.

Dogs account for the majority of adverse event reports, followed by cats. This reflects both the larger pet population and wider range of medications for these species. Flea and tick products, pain medications (NSAIDs), and heartworm preventives are among the product categories with the highest report counts across all species.

Not necessarily. A drug used by millions of pets will have more reports in absolute numbers than a niche product, even if the actual rate of adverse events is lower. The FDA uses these reports as one of many tools to evaluate drug safety, looking for patterns and statistical signals rather than raw counts alone. Always consult your veterinarian before changing any medication.